The sign for "guess" starts with a splayed 5-hand to
the side/front of the head that moves across/in-front-of your face
and ends up in an "S"-handshape.
Now, if you are thinking, "Wait, the sign for 'guess' looks a lot like
one of the versions of the sign for 'MISS,'" -- you are correct.
Those two signs (guess and miss) are done almost the
same. The specific meaning is going to rely heavily on context (the
rest of your sentence and the situation) and
your facial expression.
MISS-(fail to hit, reach, catch, meet, or otherwise make contact
The English concept of "miss" has other meanings and another sign
variation. For the version of "miss" that means the emotion of
missing someone see: MISS
You can learn
Language (ASL) online at American Sign Language University ™
ASL resources by Lifeprint.com © Dr. William Vicars